Structural communication fingerprinting and dynamic investigation of RBD-hACE2 complex from BA.1 × AY.4 recombinant variant (Deltacron) of SARS-CoV-2 to decipher the structural basis for enhanced transmission

Author:

Wang Jiangang1,Fatima Muhammad Syeda2,Aman Shafaq3,Khan Abbas45ORCID,Munir Sadaf6,Khan Mazhar7,Mohammad Anwar8,Waheed Yasir9ORCID,Munir Muhammad10,Guo Lisha11,Chen Lei12,Wei Dong-Qing4513ORCID

Affiliation:

1. The Nanyang Central Hospital, Gongnong Road, Nanyang, Henan, China

2. Wah Medical College, Wah Cantt, Punjab, Pakistan

3. King Edward Medical University, Lahore, Punjab, Pakistan

4. Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, P.R. China

5. Zhongguancun Scientific Park, Meixi, Zhongjing Research and Industrialization Institute of Chinese Medicine, Nanyang, Henan, P.R. China

6. Combined Military Hospital (CMH), Lahore, Punjab, Pakistan

7. The CAS Key Laboratory of Innate Immunity and Chronic Diseases, Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China (USTC), Collaborative Innovation Center of Genetics and Development, Hefei, Anhui, China

8. Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait

9. Office of Research, Innovation, and Commercialization (ORIC), Shaheed Zulfiqar Ali Bhutto Medical University (SZABMU), Islamabad, Pakistan

10. Division of Biomedical and Life Sciences, Lancaster University, United Kingdom

11. Zhongjing Chinese Medicine College, Nayang Institute of Technology, Nanyang, China

12. Biyang First High School, Wenming Road, Biyang, Henan, China

13. Peng Cheng Laboratory, Shenzhen, Guangdong, P.R China

Funder

the Key Research Area

Ministry of Science and Technology of China, the National Science Foundation of China

Science and Technology Commission of Shanghai Municipality

SJTU JiRLMDS Joint Research Fund and Joint Research Funds for Medical and Engineering and Scientific Research at Shanghai Jiao Tong University

Publisher

Informa UK Limited

Subject

Molecular Biology,General Medicine,Structural Biology

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