Regulation of protein-ligand binding affinity by hydrogen bond pairing-Reference-Cited by-同舟云学术

Regulation of protein-ligand binding affinity by hydrogen bond pairing

Published:2016-03-04 Issue:3 Volume:2 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Chen Deliang¹,Oezguen Numan²³^ORCID,Urvil Petri²³^ORCID,Ferguson Colin⁴^ORCID,Dann Sara M.⁵,Savidge Tor C.²³

Affiliation:

1. Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Chemistry and Chemical Engineering College, Gannan Normal University, Ganzhou, Jiangxi 341000, P. R. China.

2. Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.

3. Texas Children’s Microbiome Center, Texas Children’s Hospital, Houston, TX 77030, USA.

4. Echelon Biosciences Inc., Salt Lake City, UT 84108, USA.

5. Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.

Abstract

Receptor-ligand H-bond pairings have evolved to promote high-affinity binding by reducing competitive interference with water.

Funder

National Institute of Allergy and Infectious Diseases

National Institute of Diabetes and Digestive and Kidney Diseases

National Science Foundation of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference52 articles.

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3. Using unnatural amino acids to probe the energetics of oxyanion hole hydrogen bonds in the ketosteroid isomerase active site;Natarajan A.;J. Am. Chem. Soc.,2014

4. Asymmetric catalysis by chiral hydrogen-bond donors;Taylor M. S.;Angew. Chem. Int. Ed. Engl.,2006

5. Entropy-Enthalpy Compensation: Role and Ramifications in Biomolecular Ligand Recognition and Design

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