Structural and energetic insights into the selective inhibition of PKMYT1 against WEE1-Reference-Cited by-同舟云学术

Structural and energetic insights into the selective inhibition of PKMYT1 against WEE1

Published:2023-06-22 Issue: Volume: Page:1-9
ISSN:0739-1102
Container-title:Journal of Biomolecular Structure and Dynamics
language:en
Short-container-title:Journal of Biomolecular Structure and Dynamics

Author:

Qi Xuesen¹,Li Guozhen¹,Liu Jiahai²,Mou Linkai¹,Zhang Yusheng¹,Guo Shilin¹,Chen Xiangyu³,Li Wenxing⁴

Affiliation:

1. Department of Urology, The Affiliated Hospital of Weifang Medical University, Weifang Medical University, Weifang, Shandong, China

2. Department of Gastrointestinal and Anal Diseases Surgery, The Affiliated Hospital of Weifang Medical University, Weifang Medical University, Weifang, Shandong, China

3. School of Medical Laboratory, Weifang Medical University, Weifang, Shandong, China

4. Pathology Department, The Affiliated Hospital of Weifang Medical University, Weifang Medical University, Weifang, Shandong, China

Funder

Natural Science Foundation of Shandong Province

Seed Foundation of Affiliated Hospital of Weifang Medical University

Publisher

Informa UK Limited

Subject

Molecular Biology,General Medicine,Structural Biology

Link

https://www.tandfonline.com/doi/pdf/10.1080/07391102.2023.2225106

Reference52 articles.

1. Direct interaction between ABCA1 and HIV-1 Nef: Molecular modeling and virtual screening for inhibitors

2. Insights into the molecular mechanism of positive cooperativity between partial agonist MK-8666 and full allosteric agonist AP8 of hGPR40 by Gaussian accelerated molecular dynamics (GaMD) simulations

3. PKMYT1: a forgotten member of the WEE1 family

4. Trends in kinase drug discovery: targets, indications and inhibitor design

5. Human Myt1 Is a Cell Cycle-regulated Kinase That Inhibits Cdc2 but Not Cdk2 Activity

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1. GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer;Cell Reports;2024-08

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