Insights into the molecular mechanism of positive cooperativity between partial agonist MK-8666 and full allosteric agonist AP8 of hGPR40 by Gaussian accelerated molecular dynamics (GaMD) simulations-Reference-Cited by-同舟云学术

Insights into the molecular mechanism of positive cooperativity between partial agonist MK-8666 and full allosteric agonist AP8 of hGPR40 by Gaussian accelerated molecular dynamics (GaMD) simulations

Published:2021 Issue: Volume:19 Page:3978-3989
ISSN:2001-0370
Container-title:Computational and Structural Biotechnology Journal
language:en
Short-container-title:Computational and Structural Biotechnology Journal

Author:

An Xiaoli,Bai Qifeng,Bing Zhitong,Liu Huanxiang,Yao Xiaojun

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Computer Science Applications,Genetics,Biochemistry,Structural Biology,Biophysics,Biotechnology

Reference66 articles.

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4. A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs;Kotarsky;Biochem Biophys Res Commun,2003

5. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules;Briscoe;Br J Pharmacol,2006

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