Human pharmacokinetics prediction with an in vitro–in vivo correction factor approach and in vitro drug-drug interaction profile of bictegravir, a potent integrase-strand transfer inhibitor component in approved biktarvy® for the treatment of HIV-1 infection-Reference-Cited by-同舟云学术

Human pharmacokinetics prediction with an in vitro–in vivo correction factor approach and in vitro drug-drug interaction profile of bictegravir, a potent integrase-strand transfer inhibitor component in approved biktarvy^® for the treatment of HIV-1 infection

Published:2022-12-02 Issue:12 Volume:52 Page:1020-1030
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Subramanian Raju¹,Wang Jianhong¹,Murray Bernard¹,Custodio Joseph¹,Hao Jia¹,Lazerwith Scott¹,MacLennan Staiger Kelly¹,Mwangi Judy¹,Sun Hailing¹,Tang Jennifer¹,Wang Kelly¹,Rhodes Gerry¹,Wijaya Samantha¹,Zhang Heather¹,Smith Bill J.¹

Affiliation:

1. Gilead Sciences, Inc, Foster City, CA, USA

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2023.2169207

Reference33 articles.

1. Determination of Hepatic Clearance with the Account of Drug–Protein Binding Kinetics

2. Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies

3. Efficacy and safety of switching to fixed-dose bictegravir, emtricitabine, and tenofovir alafenamide from boosted protease inhibitor-based regimens in virologically suppressed adults with HIV-1: 48 week results of a randomised, open-label, multicentre, phase 3, non-inferiority trial

4. In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method

5. [EMA] European Medicines Agency 2018. Public assessment report Biktarvy®. https://www.ema.europa.eu/documents/assessment-report/biktarvy-epar-public-assessment-report_en.pdf

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1. Effect of ABCB1 most frequent polymorphisms on the accumulation of bictegravir in recombinant HEK293 cell lines;Scientific Reports;2024-07-15

2. Induction effect of antiretroviral bictegravir on the expression of Abcb1, Abcg2 and Abcc1 genes associated with P-gp, BCRP and MRP1 transporters present in rat peripheral blood mononuclear cells;Expert Opinion on Drug Metabolism & Toxicology;2024-05-13

3. Expanding therapeutic options: lenacapavir + bictegravir as a potential treatment for HIV;Expert Opinion on Pharmacotherapy;2023-12-12