<i>In vitro</i> and <i>in vivo</i> studies on the metabolism and pharmacokinetics of the selective gut microbial β-glucuronidase targeting compound Inh 1-Reference-Cited by-同舟云学术

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In vitro and in vivo studies on the metabolism and pharmacokinetics of the selective gut microbial β-glucuronidase targeting compound Inh 1

Published:2024-06-12 Issue:6 Volume:54 Page:304-315
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Kerins Anna¹,Butler Phil¹,Riley Rob¹,Koszyczarek Marta¹,Smith Caroline¹,Cruickshank Faye¹,Madgula Vamsi²,Naik Nilkanth²,Redinbo Matthew R.³⁴⁵,Wilson Ian D.⁶

Affiliation:

1. Cyprotex Discovery, Macclesfield, UK

2. DMPK and Toxicology, Sai Life Sciences Limited, DS-7, ICICI Knowledge Park, Hyderabad, India

3. Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA

4. Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA

5. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA

6. Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College, London, UK

Publisher

Informa UK Limited

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2024.2357765

Reference25 articles.

1. Gastrointestinal Damage Associated with the Use of Nonsteroidal Antiinflammatory Drugs

2. Nonsteroidal Anti-Inflammatory Drug-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells

3. Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy

4. Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans

5. NSAID Acyl Glucuronides and Enteropathy

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