Comprehensive identification, fragmentation pattern, and metabolic pathways of gefitinib metabolites via UHPLC-Q-TOF-MS/MS: in vivo study of rat plasma, urine, bile, and faeces-Reference-Cited by-同舟云学术

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Comprehensive identification, fragmentation pattern, and metabolic pathways of gefitinib metabolites via UHPLC-Q-TOF-MS/MS: in vivo study of rat plasma, urine, bile, and faeces

Published:2021-01-04 Issue:3 Volume:51 Page:355-365
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Gao Xun¹²^ORCID,Zhang Yue¹,Feng Tiantian³,Cao Lei¹,Wu Wenjing¹,Qin Kunming¹

Affiliation:

1. School of Pharmacy, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Ocean University, Lianyungang, P. R. China

2. Jiangsu Yuanchuang Pharmaceutical Research and Development Co., Ltd., Lianyungang, P. R. China

3. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, P. R. China

Funder

Jiangsu Higher Education Institutions

Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2020.1859642

Reference29 articles.

1. EGFR Inhibitor Gefitinib Induces Cardiotoxicity through the Modulation of Cardiac PTEN/Akt/FoxO3a Pathway and Reactive Metabolites Formation: In Vivo and in Vitro Rat Studies

2. Future of ToxicologyMetabolic Activation and Drug Design: Challenges and Opportunities in Chemical Toxicology

3. Carboxylic Acid (Bio)Isosteres in Drug Design

4. Pharmacokinetics of gefitinib in humans: The influence of gastrointestinal factors

5. FDA Drug Approval Summary: Gefitinib (ZD1839) (Iressa®) Tablets

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1. Identification and characterization of the rat in-vivo and in-vitro metabolites of tazemetostat using LC-QTOF-MS;Food and Chemical Toxicology;2024-08

2. Detection of pharmacolipidodynamic effects following the intravenous and oral administration of gefitinib to C57Bl/6JRj mice by rapid UHPLC-MS analysis of plasma;Scientific Reports;2024-07-24

3. Detection of Pharmacolipidodynamic Effects Following the Intravenous and Oral Administration of Gefitinib to C57Bl/6JRj Mice by Rapid UHPLC/MS Analysis of Plasma;2023-10-04

4. Identification and analysis of chemical constituents of total glycosides of Cistanche deserticola YC Ma in rat hepatic metabolism by ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry (UPLC-Q-TOF-MS);Materials Express;2022-08-01

5. The Pharmacometabodynamics of Gefitinib after Intravenous Administration to Mice: A Preliminary UPLC–IM–MS Study;Metabolites;2021-06-11

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