Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established <i>in vitro</i> to <i>in vivo</i> extrapolation methodologies-Reference-Cited by-同舟云学术

Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies

Published:2022-06-03 Issue:6 Volume:52 Page:591-607
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Langthaler Kristine¹²,Jones Christopher R.¹,Christensen Rasmus B.¹,Eneberg Elin¹,Brodin Birger²,Bundgaard Christoffer¹

Affiliation:

1. Translational DMPK, H. Lundbeck A/S, Copenhagen, Denmark

2. CNS Drug Delivery and Barrier Modelling, University of Copenhagen, Copenhagen, Denmark

Funder

H. Lundbeck A/S and Innovation Fund Denmark

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2022.2115425

Reference63 articles.

1. Cytochrome P450 Pig Liver Pie: Determination of Individual Cytochrome P450 Isoform Contents in Microsomes from Two Pig Livers Using Liquid Chromatography in Conjunction with Mass Spectrometry

2. The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties

3. THE BINDING OF DRUGS TO HEPATOCYTES AND ITS RELATIONSHIP TO PHYSICOCHEMICAL PROPERTIES

4. The utility of the minipig as an animal model in regulatory toxicology

5. The Göttingen Minipig in Pharmacology and Toxicology

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