Dioscorea bulbifera L. delays the excretion of doxorubicin and aggravates doxorubicin-induced cardiotoxicity and nephrotoxicity by inhibiting the expression of P-glycoprotein in mice liver and kidney-Reference-Cited by-同舟云学术

Dioscorea bulbifera L. delays the excretion of doxorubicin and aggravates doxorubicin-induced cardiotoxicity and nephrotoxicity by inhibiting the expression of P-glycoprotein in mice liver and kidney

Published:2019-05-15 Issue:9 Volume:49 Page:1116-1125
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Qu Xiaoyu¹^ORCID,Zhai Jinghui¹,Hu Tingting²,Gao Huan¹,Tao Lina¹,Zhang Yueming¹,Song Yanqing¹,Zhang Sixi¹

Affiliation:

1. Department of Pharmacy, the First Hospital of Jilin University, Changchun, PR China;

2. Department of Technical center, Jilin Entry Exit Inspection and Quarantine Bureau, Changchun, PR China

Funder

the National Natural Science Foundation of China

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2018.1498560

Reference27 articles.

1. The cardioprotector monoHER does not interfere with the pharmacokinetics or the metabolism of the cardiotoxic agent doxorubicin in mice

2. Doxorubicin targets multiple players: A new view of an old problem

3. In vitro drug–drug interactions of budesonide: inhibition and induction of transporters and cytochrome P450 enzymes

4. Effects of 17α-ethynylestradiol-induced cholestasis on the pharmacokinetics of doxorubicin in rats: reduced biliary excretion and hepatic metabolism of doxorubicin

5. In vivodisposition of doxorubicin is affected by mouse Oatp1a/1b and human OATP1A/1B transporters

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