In vivo hepatic clearance of lipophilic drugs predicted by in vitro uptake data into cryopreserved hepatocytes suspended in sera of rats, guinea pigs, monkeys and humans-Reference-Cited by-同舟云学术

In vivo hepatic clearance of lipophilic drugs predicted by in vitro uptake data into cryopreserved hepatocytes suspended in sera of rats, guinea pigs, monkeys and humans

Published:2018-09-21 Issue:8 Volume:49 Page:887-894
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Koyanagi Takashi¹,Yano Koji¹,Kim Soonih¹,Murayama Norie²,Yamazaki Hiroshi²^ORCID,Tamai Ikumi³

Affiliation:

1. Discovery Technology Research Laboratories, Ono Pharmaceutical Co., Ltd, Osaka, Japan;

2. Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan;

3. Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2018.1514476

Reference32 articles.

1. Steady-state dispositions of valproate and diflunisal alone and coadministered to healthy volunteers

2. Kinetic determinants of hepatic clearance: Plasma protein binding and hepatic uptake

3. Prediction of hepatic clearance using cryopreserved human hepatocytes: a comparison of serum and serum-free incubations

4. Glucuronidation of diflunisal in liver and kidney microsomes of rat and man

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Exploring the Boundaries for In Vitro–In Vivo Extrapolation: Use of Isolated Rat Hepatocytes in Co-culture and Impact of Albumin Binding Properties in the Prediction of Clearance of Various Drug Types;Drug Metabolism and Disposition;2023-08-14

2. Analysis of Time-Dependent Pharmacokinetics Using In Vitro–In Vivo Extrapolation and Physiologically Based Pharmacokinetic Modeling;Pharmaceutics;2022-11-22

3. Comparative hepatotoxicity of a herbicide, epyrifenacil, in humans and rodents by comparing the dynamics and kinetics of its causal metabolite;Journal of Pesticide Science;2021-11-20

4. A New Guidance for the Prediction of Hepatic Clearance in the Early Drug Discovery and Development from the in Vitro-to-in Vivo Extrapolation Method and an Approach for Exploring Whether an Albumin-Mediated Hepatic Uptake Phenomenon Could be Present Under in Vivo Conditions;Journal of Pharmaceutical Sciences;2021-07

5. Comparison of In Vitro to In Vivo Extrapolation Approaches for Predicting Transporter-Mediated Hepatic Uptake Clearance Using Suspended Rat Hepatocytes;Drug Metabolism and Disposition;2020-08-05