Regioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6-Reference-Cited by-同舟云学术

Regioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6

Published:2019-06-14 Issue:11 Volume:49 Page:1323-1331
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Uehara Shotaro¹^ORCID,Murayama Norie²,Yamazaki Hiroshi²^ORCID,Suemizu Hiroshi¹^ORCID

Affiliation:

1. Central Institute for Experimental Animals, Kawasaki, Japan;

2. Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan

Funder

Platform Project for Supporting Drug Discovery

Life Science Research (Basis for Supporting Innovative Drug Discovery

Young Scientists B

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2018.1564401

Reference19 articles.

1. Minipig as a model for drug metabolism in man: Comparison of in vitro and in vivo metabolism of propafenone

2. The metabolic fate of2H-labelled propafenone in man

3. Catalytic Specificity of CYP2D Isoforms in Rat and Human

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