Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers
Author:
Funder
Japan Society for the Promotion of Science
Japan Agency for Medical Research and Development
Publisher
Elsevier BV
Subject
Pharmacology (medical),Pharmaceutical Science,Pharmacology
Reference13 articles.
1. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation;Zanger;Pharmacol Ther,2013
2. Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, Guinea pigs, dogs, monkeys, and humans;Shimada;Arch Toxicol,1997
3. Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes;Uehara;Xenobiotica,2021
4. Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes;Uehara;Xenobiotica,2020
5. Formation of the accumulative human metabolite and human-specific glutathione conjugate of diclofenac in TK-NOG chimeric mice with humanized livers;Kamimura;Drug Metab Dispos,2015
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