Validation of a total IC50 method which enables in vitro assessment of transporter inhibition under semi-physiological conditions-Reference-Cited by-同舟云学术

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Validation of a total IC50 method which enables in vitro assessment of transporter inhibition under semi-physiological conditions

Published:2016-10-03 Issue:9 Volume:47 Page:825-832
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Kikuchi Ryota¹,Peterkin Vincent C.¹,Chiou William J.¹,de Morais Sonia M.¹,Bow Daniel A. J.¹

Affiliation:

1. Department of Drug Metabolism and Pharmacokinetics, AbbVie Inc, North Chicago, IL, USA

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2016.1233372

Reference28 articles.

1. Clinical pharmacokinetics and pharmacodynamics of dolutegravir used as a single tablet regimen for the treatment of HIV-1 infection

2. In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development

3. Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia

4. In vitroOATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia

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2. Reimagining the Framework Supporting the Static Analysis of Transporter Drug Interaction Risk; Integrated Use of Biomarkers to Generate Pan‐Transporter Inhibition Signatures;Clinical Pharmacology & Therapeutics;2022-08-10

3. Challenges and Opportunities for Improved Drug–Drug Interaction Predictions for Renal OCT2 and MATE1/2‐K Transporters;Clinical Pharmacology & Therapeutics;2022-06-25

4. Application of a physiologically based pharmacokinetic model of rivaroxaban to prospective simulations of drug–drug–disease interactions with protein kinase inhibitors in cancer‐associated venous thromboembolism;British Journal of Clinical Pharmacology;2022-01-05

5. Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interaction Potential of Vemurafenib Using R-Value and Physiologically-Based Pharmacokinetic Models;Journal of Pharmaceutical Sciences;2021-01

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