Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection

Author:

Jia Wenxu1,Channappanavar Rudragouda23,Zhang Chao45,Li Mingxi1,Zhou Haixia6,Zhang Shuyuan6,Zhou Panpan1,Xu Jiuyang1ORCID,Shan Sisi1,Shi Xuanling1,Wang Xinquan6,Zhao Jincun7,Zhou Dongming5,Perlman Stanley27ORCID,Zhang Linqi1ORCID

Affiliation:

1. Comprehensive AIDS Research Center, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, People’s Republic of China

2. Department of Microbiology and Immunology, The University of Iowa, Iowa City, IA, USA

3. Department of Acute and Tertiary Care, and the Institute for the Study of Host–Pathogen Systems, University of Tennessee Health Science Center, Memphis, TN, USA

4. School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China

5. Key Laboratory of Molecular Virology & Immunology, Vaccine Research Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People’s Republic of China

6. The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, Beijing, People’s Republic of China

7. State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China

Funder

Chinese Academy of Sciences

National Natural Science Foundation of China

National Science and Technology Development Agency

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

Reference65 articles.

1. Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

2. Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003

3. WHO. Middle East respiratory syndrome coronavirus (MERS-CoV); 2019 http://www.who.int/emergencies/mers-cov/en/

4. WHO. Middle East respiratory syndrome coronavirus (MERS-CoV); 2017 http://www.who.int/emergencies/mers-cov/en/

5. Asymptomatic SARS Coronavirus Infection among Healthcare Workers, Singapore

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