Cross-reactive antibody against human coronavirus OC43 spike protein correlates with disease severity in COVID-19 patients: a retrospective study

Author:

Guo Li12,Wang Yeming3,Kang Liang4,Hu Yongfeng1,Wang Linghang5,Zhong Jingchuan1,Chen Hong6,Ren Lili12,Gu Xiaoying7,Wang Geng1,Wang Conghui1,Dong Xiaojing1,Wu Chao1,Han Lianlian1,Wang Ying1,Fan Guohui7,Zou Xiaohui3,Li Haibo38,Xu Jiuyang9,Jin Qi1,Cao Bin3810ORCID,Wang Jianwei12ORCID

Affiliation:

1. NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China

2. Key Laboratory of Respiratory Disease Pathogenomics and Christophe Mérieux Laboratory, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China

3. Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China–Japan Friendship Hospital, Beijing, People’s Republic of China

4. Jin Yin-tan Hospital, Wuhan, People’s Republic of China

5. Emergency Department of Infectious Diseases of Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China

6. The Second Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China

7. Institute of Clinical Medical Sciences, China–Japan Friendship Hospital, Beijing, People’s Republic of China

8. Institute of Respiratory Medicine, Chinese Academy of Medical Science, Beijing, People’s Republic of China

9. Tsinghua University School of Medicine, Beijing, People’s Republic of China

10. Department of Respiratory Medicine, Capital Medical University, Beijing, People’s Republic of China

Funder

the National Major Science & Technology Project for Control and Prevention of Major Infectious Diseases in China

Chinese Academy of Medical Sciences

Innovation Fund for Medical Sciences

Natural Science Foundation of China

National Key

R&D Program of China

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

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