Heterologous booster with inhaled adenovirus vector COVID-19 vaccine generated more neutralizing antibodies against different SARS-CoV-2 variants

Author:

Zhong Jiaying12,Liu Shuo3,Cui Tingting12,Li Jingxin4,Zhu Fengcai4ORCID,Zhong Nanshan12,Huang Weijin3ORCID,Zhao Zhuxiang5,Wang Zhongfang12

Affiliation:

1. State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, People’s Republic of China

2. Guangzhou Laboratory, Guangzhou, People’s Republic of China

3. National Institutes for Food and Drug Control, NHC Key Laboratory of Research on Quality and Standardization of Biotech Products & NMPA Key Laboratory for Quality Research and Evaluation of Biological Products Beijing, Beijing, People’s Republic of China

4. NHC Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, People’s Republic of China

5. Department of Infectious Disease, Respiratory and Critical Care Medicine, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China

Funder

State Key Basic Research Project

Ministry of Science and Technology of China

NSFC

Guangdong Key Basic Research Project

Emergency Key Program of Guangzhou Laboratory

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

Reference21 articles.

1. Why does the Omicron sub-variant spread faster than the original?

2. Coronavirus disease (COVID-19): weekly epidemiological update. 2022. Available from: https://reliefweb.int/report/world/coronavirus-disease-covid-19-weekly-epidemiological-update-29-june-2022.

3. Control CfD, Prevention. Centers for disease control and prevention COVID data tracker: vaccination demographics trends. 2021.

4. SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity

5. BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

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