The problem of racemization in drug discovery and tools to predict it-Reference-Cited by-同舟云学术

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The problem of racemization in drug discovery and tools to predict it

Published:2019-03-18 Issue:6 Volume:14 Page:527-539
ISSN:1746-0441
Container-title:Expert Opinion on Drug Discovery
language:en
Short-container-title:Expert Opinion on Drug Discovery

Author:

Ballard Andrew¹,Narduolo Stefania¹,Ahmad Hiwa O.¹²,Cosgrove David A.³,Leach Andrew G.⁴,Buurma Niklaas J.¹

Affiliation:

1. Physical Organic Chemistry Centre, School of Chemistry, Cardiff University, Cardiff, UK

2. Pharmaceutical Chemistry Department, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq

3. CozChemIx Limited, Macclesfield

4. School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK

Funder

Engineering and Physical Sciences Research Council

Publisher

Informa UK Limited

Subject

Drug Discovery

Link

https://www.tandfonline.com/doi/pdf/10.1080/17460441.2019.1588881

Reference56 articles.

1. Chiral Toxicology: It's the Same Thing…Only Different

2. Organic Stereochemistry. Part 5

3. Trends in the development of chiral drugs

4. Pharmacological Importance of Stereochemical Resolution of Enantiomeric Drugs

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1. Investigating the Origin of Epimerization Attenuation during Pd-Catalyzed Cross-Coupling Reactions;ACS Catalysis;2024-08-03

2. Study on the stability of molecular chirality and the configuration protection of dihydromyricetin in vine tea;Journal of Food Science;2024-05-14

3. Union is strength: π–π stacking interactions are capable of preventing solid-state racemization of tris-chelate complexes;CrystEngComm;2024

4. Elucidating the Racemization Mechanism of Aliphatic and Aromatic Amino Acids by In Silico Tools;International Journal of Molecular Sciences;2023-07-25

5. Discovery of Acyl-Indole Derivatives as Pan-Serotype Dengue Virus NS4B Inhibitors;Journal of Medicinal Chemistry;2023-06-30

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