Approaches to mitigate the risk of serious adverse reactions in covalent drug design
Author:
Affiliation:
1. Department of Medicinal Chemistry, School of Pharmacy, University of Washington Seattle, Seattle, WA, USA
Funder
not funded
Publisher
Informa UK Limited
Subject
Drug Discovery
Link
https://www.tandfonline.com/doi/pdf/10.1080/17460441.2021.1832079
Reference90 articles.
1. The resurgence of covalent drugs
2. The Taxonomy of Covalent Inhibitors
3. Covalent Modifiers: An Orthogonal Approach to Drug Design
4. Beyond Picomolar Affinities: Quantitative Aspects of Noncovalent and Covalent Binding of Drugs to Proteins
5. Strategies for discovering and derisking covalent, irreversible enzyme inhibitors
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