Carbonic Anhydrase Inhibitors With Strong Topical Antiglaucoma Properties Incorporating a 4-(2-amino-pyrimidin-4-yl-amino)-benzenesulfonamide Scaffold

Author:

Casini Angela1,Mincione Francesco2,Vullo Daniela1,Menabuoni Luca3,Scozzafava Andrea4,Supuran Claudiu T.1

Affiliation:

1. Università degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della Lastruccia, 3, I-50019 Sesto Fiorentino Firenze, Italy

2. Università degli Studi, Istituto Oculistico, Viale Morgagni 85, I-50134 Firenze, and U.O. Oculistica Az. USL 3, Val di Nievole, Ospedale di Pescia, Pescia, Italy

3. Ospedale San Giovanni di Dio, U.O. Oculistica, Via Torregalli 3, I-50123, Firenze, Italy

4. CSGI, c/o Università degli Studi di Firenze, Via Gino Capponi 7, I-50121, Firenze, Italy

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Reference39 articles.

1. Supuran, C.T. and Scozzafava, A. (2001), Curr. Med. Chem. Imm., Endoc., Metab. Agents 1, 61-97.

2. Supuran, C.T. and Scozzafava, A. (2000), Exp. Opin. Ther.Patents 10, 575-600.

3. Supuran, C.T. (1994) "Carbonic anhydrase inhibitors", In: Puscas, I., eds, Carbonic Anhydrase and Modulation of Physiologic and Pathologic Processes in the Organism (Helicon, Timisoara, Roumania), pp 29-111.

4. Maren, T.H. (2000) "Carbonic anhydrase inhibition in ophthalmology: aqueous humor secretion and development of sulphonamide inhibitors", The Carbonic Anhydrases-New Horizons (Birkhäuser, Basel), pp 425-436.

5. Maren, T.H., Jankowska, L., Sanyal, G. and Edelhauser, G.F. (1983), Exp. Eye Res. 36, 457-480.

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