Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies-Reference-Cited by-同舟云学术

Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies

Published:2023-09-12 Issue:1 Volume:15 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Mock Marissa¹^ORCID,Jacobitz Alex W.²,Langmead Christopher James¹,Sudom Athena³,Yoo Daniel¹,Humphreys Sara C.⁴,Alday Mai¹,Alekseychyk Larysa²,Angell Nicolas²,Bi Vivian¹,Catterall Hannah¹,Chen Chen-Chun¹,Chou Hui-Ting³,Conner Kip P.⁴,Cook Kevin D.⁴,Correia Ana R.¹,Dykstra Andrew²,Ghimire-Rijal Sudipa⁵,Graham Kevin¹,Grandsard Peter¹,Huh Joon²,Hui John O.¹,Jain Mani¹,Jann Victoria¹,Jia Lei¹,Johnstone Sheree³,Khanal Neelam²,Kolvenbach Carl¹,Narhi Linda²,Padaki Rupa²,Pelegri-O’Day Emma M.¹,Qi Wei²,Razinkov Vladimir²,Rice Austin J.¹,Smith Richard⁴,Spahr Christopher¹,Stevens Jennitte²,Sun Yax¹,Thomas Veena A.⁴,van Driesche Sarah¹,Vernon Robert¹,Wagner Victoria¹,Walker Kenneth W.¹,Wei Yangjie²,Winters Dwight¹,Yang Melissa¹,Campuzano Iain D. G.¹

Affiliation:

1. Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USA

2. Process Development, Amgen Operations, Thousand Oaks, CA, USA

3. Structural Biology, Amgen Research, South San Francisco, CA, USA

4. Pharmacokinetics & Drug Metabolism, Amgen Research, South San Francisco, CA, USA

5. Structural Biology, Amgen Research, Thousand Oaks, CA, USA

Funder

no funding

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy