Controlled conductivity at low pH in Protein L chromatography enables separation of bispecific and other antibody formats by their binding valency-Reference-Cited by-同舟云学术

Controlled conductivity at low pH in Protein L chromatography enables separation of bispecific and other antibody formats by their binding valency

Published:2019-03-21 Issue:4 Volume:11 Page:632-638
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Chen Chen¹,Wakabayashi Tetsuya²^ORCID,Muraoka Masaru¹^ORCID,Shu Feng¹,Wei Shan Chia¹,Chor Kun Chong¹,Tim Jang Ching¹,Soehano Ishin¹,Shimizu Yuichiro¹²^ORCID,Igawa Tomoyuki²³,Nezu Jun-Ichi⁴

Affiliation:

1. Antibody Generation Group, Research Division, Chugai Pharmabody Research Pte. Ltd, Singapore

2. Discovery Biologics Department, Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan

3. Research Division, Chugai Pharmabody Research Pte. Ltd., Synapse, Singapore

4. Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2019.1583996

Reference33 articles.

1. Alternative molecular formats and therapeutic applications for bispecific antibodies

2. Challenges and opportunities for non-antibody scaffold drugs

3. An anti–glypican 3/CD3 bispecific T cell–redirecting antibody for treatment of solid tumors

4. A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model

5. Bispecific antibodies

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