Dose escalation PET imaging for safety and effective therapy dose optimization of a bispecific antibody-Reference-Cited by-同舟云学术

Dose escalation PET imaging for safety and effective therapy dose optimization of a bispecific antibody

Published:2020-01-01 Issue:1 Volume:12 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Wang Yan¹²,Pan Donghui³,Huang Chenrong¹²,Chen Bingliang⁴,Li Mingzhu³,Zhou Shuaixiang⁴,Wang Lizhen³,Wu Min⁴,Wang Xinyu³,Bian Yicong¹²,Yan Junjie³,Liu Junjian⁴,Yang Min³,Miao Liyan¹²

Affiliation:

1. Department of Clinical Pharmacology, The First Affiliated Hospital of Soochow University, Suzhou, China

2. Institute for Interdisciplinary Drug Research and Translational Sciences, College of Pharmaceutical Sciences, Soochow University, Suzhou, China

3. NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, China

4. Drug Discovery Department, Innovent Biopharmaceutical (Suzhou) Co., Ltd, Suzhou, China

Funder

the Special Research Fund of Wu Jieping Medical Foundation of Chinese Society of Clinical Pharmacy

the National Natural Science Foundation of China

the Jiangsu Provincial Medical Innovation Team

the National Significant New Drugs Creation Program

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2020.1748322

Reference31 articles.

1. Immuno-PET to Optimize the Dose of Monoclonal Antibodies for Cancer Therapy: How Much Is Enough?

2. An FDA oncology analysis of CD3 bispecific constructs and first-in-human dose selection

3. An FDA oncology analysis of immune activating products and first-in-human dose selection

4. Immuno-PET Imaging to Assess Target Engagement: Experience from 89Zr-Anti-HER3 mAb (GSK2849330) in Patients with Solid Tumors

5. Role of receptor occupancy assays by flow cytometry in drug development

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