Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site-Reference-Cited by-同舟云学术

Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site

Published:2020-01-01 Issue:1 Volume:12 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Hanf Karl J. M.¹^ORCID,Arndt Joseph W.¹,Liu YuTing¹,Gong Bang Jian¹,Rushe Mia¹,Sopko Richelle¹,Massol Ramiro²,Smith Benjamin¹,Gao Yan²,Dalkilic-Liddle Isin¹,Lee Xinhua²,Mojta Shanell¹,Shao Zhaohui²,Mi Sha²,Pepinsky R. Blake¹

Affiliation:

1. Biotherapeutic and Medicinal Sciences, Biogen, Cambridge, MA, USA

2. Research and Early Development, Biogen, Cambridge, MA, USA

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2020.1713648

Reference30 articles.

1. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

2. LINGO-1 negatively regulates myelination by oligodendrocytes

3. A decade from discovery to therapy: Lingo-1, the dark horse in neurological and psychiatric disorders

4. Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models

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