Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics
Author:
Affiliation:
1. BioMedicine Design, Pfizer Inc., Cambridge, MA, USA
2. BioMedicine Design, Pfizer Inc., Andover, MA, USA
Publisher
Informa UK Limited
Subject
Immunology,Immunology and Allergy
Link
https://www.tandfonline.com/doi/pdf/10.1080/19420862.2017.1389355
Reference50 articles.
1. Monoclonal Antibody Pharmacokinetics and Pharmacodynamics
2. Increasing the Affinity of a Human IgG1 for the Neonatal Fc Receptor: Biological Consequences
3. pH-dependent Binding Engineering Reveals an FcRn Affinity Threshold That Governs IgG Recycling
4. Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn)
5. Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics
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