Productive common light chain libraries yield diverse panels of high affinity bispecific antibodies
Author:
Affiliation:
1. Oncology Research and Development, Pfizer Inc., South San Francisco, CA, USA
Publisher
Informa UK Limited
Subject
Immunology,Immunology and Allergy
Link
https://www.tandfonline.com/doi/pdf/10.1080/19420862.2017.1406570
Reference64 articles.
1. Immunotherapy of lymphoma and leukemia with T-cell engaging BiTE antibody blinatumomab
2. Antitumor Activity of a Novel Bispecific Antibody That Targets the ErbB2/ErbB3 Oncogenic Unit and Inhibits Heregulin-Induced Activation of ErbB3
3. A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity
4. Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target
5. Improving target cell specificity using a novel monovalent bispecific IgG design
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