Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target-Reference-Cited by-同舟云学术

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

Published:2011-05-25 Issue:84 Volume:3 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Yu Y. Joy¹,Zhang Yin²,Kenrick Margaret³,Hoyte Kwame⁴,Luk Wilman⁴,Lu Yanmei⁴,Atwal Jasvinder¹,Elliott J. Michael⁵,Prabhu Saileta³,Watts Ryan J.¹,Dennis Mark S.²

Affiliation:

1. Neurodegeneration Labs, Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA.

2. Department of Antibody Engineering, Genentech Inc., South San Francisco, CA 94080, USA.

3. Department of Developmental Sciences, Genentech Inc., South San Francisco, CA 94080, USA.

4. Department of Assay Automation Technology, Genentech Inc., South San Francisco, CA 94080, USA.

5. Department of Protein Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.

Abstract

Brain uptake of a therapeutic bispecific antibody by receptor-mediated transcytosis is enhanced by reducing the antibody’s affinity for the transferrin receptor.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference15 articles.

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3. Blood–Brain Barrier Transport of Therapeutics via Receptor-Mediation

4. Immunohistochemical localization of the murine transferrin receptor (TfR) on blood-tissue barriers using a novel anti-TfR monoclonal antibody

5. Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse.;Lee H. J.;J. Pharmacol. Exp. Ther.,2000

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