A novel bicistronic gene design couples stable cell line selection with a fucose switch in a designer CHO host to produce native and afucosylated glycoform antibodies-Reference-Cited by-同舟云学术

A novel bicistronic gene design couples stable cell line selection with a fucose switch in a designer CHO host to produce native and afucosylated glycoform antibodies

Published:2018-02-22 Issue:3 Volume:10 Page:416-430
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Roy Gargi¹,Martin Tom¹^ORCID,Barnes Arnita¹,Wang Jihong²,Jimenez Rod Brian²,Rice Megan¹,Li Lina³,Feng Hui¹,Zhang Shu¹,Chaerkady Raghothama¹,Wu Herren¹,Marelli Marcello¹,Hatton Diane⁴,Zhu Jie³,Bowen Michael A.¹

Affiliation:

1. Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America

2. Analytical Biochemistry, MedImmune LLC, Gaithersburg, Maryland, United States of America

3. Cell Culture and Fermentation Sciences, MedImmune LLC, Gaithersburg, Maryland, United States of America

4. Cell Culture and Fermentation Sciences, Biopharmaceutical Development, MedImmune, Cambridge, United Kingdom

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2018.1433975

Reference55 articles.

1. CHO cells in biotechnology for production of recombinant proteins: current state and further potential

2. Cell culture processes for monoclonal antibody production

3. Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation

4. Glycosylation of Therapeutic Proteins

5. Modifications of Glycans: Biological Significance and Therapeutic Opportunities

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