Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach-Reference-Cited by-同舟云学术

Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach

Published:2018-05-14 Issue:5 Volume:10 Page:751-764
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Betts Alison¹,Keunecke Anne²^ORCID,van Steeg Tamara J.²,van der Graaf Piet H.³,Avery Lindsay B.⁴^ORCID,Jones Hannah¹,Berkhout Jan²

Affiliation:

1. Department of Biomedicine Design, Pfizer Inc., Cambridge, MA, USA

2. LAP&P, The Netherlands

3. Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, RA Leiden, The Netherlands

4. Department of Biomedicine Design, Pfizer Inc., Andover, MA, USA

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2018.1462429

Reference37 articles.

1. Drug Development of Therapeutic Monoclonal Antibodies

2. Pharmacokinetics of Monoclonal Antibodies

3. Elimination mechanisms of therapeutic monoclonal antibodies

4. The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor.

5. The Application of Target Information and Preclinical Pharmacokinetic/Pharmacodynamic Modeling in Predicting Clinical Doses of a Dickkopf-1 Antibody for Osteoporosis

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