Physicochemical and biological impact of metal-catalyzed oxidation of IgG1 monoclonal antibodies and antibody-drug conjugates via reactive oxygen species-Reference-Cited by-同舟云学术

Physicochemical and biological impact of metal-catalyzed oxidation of IgG1 monoclonal antibodies and antibody-drug conjugates via reactive oxygen species

Published:2022-09-24 Issue:1 Volume:14 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Glover Zephania Kwong¹,Wecksler Aaron²,Aryal Baikuntha³,Mehta Shrenik¹,Pegues Melissa³,Chan Wayman¹,Lehtimaki Mari³,Luo Allen⁴,Sreedhara Alavattam¹,Rao V. Ashutosh³^ORCID

Affiliation:

1. Pharmaceutical Development, Genentech Inc, South San Francisco, CA, USA

2. Analytical Development, Genentech Inc, South San Francisco, CA, USA

3. Laboratory of Applied Biochemistry, Division of Biotechnology Research and Review III, Office of Biotechnology Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Maryland, USA

4. Biological Technologies, Genentech Inc, South San Francisco, CA, USA

Funder

This work was supported by the

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2022.2122957

Reference93 articles.

1. Biologics vs. small molecules: Drug costs and patient access

2. Methionine, tryptophan, and histidine oxidation in a model protein, PTH: Mechanisms and stabilization