Improved Impurity Profile of Phosphorothioate Oligonucleotides Through the Use of Dimeric Phosphoramidite Synthons
Author:
Publisher
Informa UK Limited
Subject
Genetics,Biochemistry
Reference20 articles.
1. Kisner, D. L. 12th International Roundtable on Nucleosides and Nucleotides. September19. La Jolla, CA, USA
2. An investigation of several deoxynucleoside phosphoramidites useful for synthesizing deoxyoligonucleotides
3. Sequence identity of then-1 product of a synthetic oligonucleotide
4. Investigation of the ‘n–1’ impurity in phosphorothioate oligodeoxynucleotides synthesized by the solid-phase β-cyanoethyl phosphoramidite method using stepwise sulfurization
5. Improved Procedure for the Reduction of N - 1 Content in Synthetic Oligonucleotides
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3. Enzymatic Regioselective Levulinylation of 2′‐Deoxyribonucleosides and 2′‐ O ‐Methylribonucleosides;Current Protocols in Nucleic Acid Chemistry;2005-06
4. Novel enzymatic synthesis of levulinyl protected nucleosides useful for solution phase synthesis of oligonucleotides;Tetrahedron: Asymmetry;2003-11
5. Synthesis of High-Quality Antisense Drugs. Addition of Acrylonitrile to Phosphorothioate Oligonucleotides: Adduct Characterization and Avoidance;Organic Process Research & Development;2003-09-25
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