Synthesis of High-Quality Antisense Drugs. Addition of Acrylonitrile to Phosphorothioate Oligonucleotides: Adduct Characterization and Avoidance
Author:
Affiliation:
1. Isis Pharmaceuticals, Inc., 2292 Faraday Avenue,Carlsbad, California 92008, U.S.A.
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op020090n
Reference44 articles.
1. Antisense Research and Application
2. Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo
3. Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase
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