Defined approaches to classify agrochemical formulations into EPA hazard categories developed using EpiOcular TM reconstructed human corneal epithelium and bovine corneal opacity and permeability assays

Author:

van der Zalm Anna J.1,Daniel Amber B.2,Raabe Hans A.3,Choksi Neepa2,Flint Silva Tara4,Breeden-Alemi Julie4,O’Dell Lindsay5,Kleinstreuer Nicole C.6,Lowit Anna B.5,Allen David G.2,Clippinger Amy J.1

Affiliation:

1. PETA Science Consortium International e.V., Stuttgart, Germany

2. Inotiv, Research Triangle Park, NC, USA

3. Institute for In Vitro Sciences, Inc, Gaithersburg, MD, USA

4. US Environmental Protection Agency Office of Pesticide Programs, Washington, DC, USA

5. US Environmental Protection Agency Office of Pollution Prevention and Toxics, Washington, DC, USA

6. National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, NC, USA

Funder

National Institute of Environmental Health Sciences, National Institute of Health

National Institutes of Health Intramural Research

Publisher

Informa UK Limited

Subject

Toxicology,General Medicine

Reference29 articles.

1. U.S. Environmental Protection Agency. New approach methods work plan (v2). Washington, DC: U.S. Environmental Protection Agency; 2021.

2. Office of Pesticide Programs. Use of an alternative testing framework for classification of eye irritation potential of EPA pesticide products. Washington, DC: US Environmental Protection Agency; 2015.

3. Test No. 467: Defined Approaches for Serious Eye Damage and Eye Irritation

4. A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom–Up and Top–Down approaches

5. A framework for establishing scientific confidence in new approach methodologies

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