Huperzine A for the treatment of cognitive, mood, and functional deficits after moderate and severe TBI (HUP-TBI): results of a Phase II randomized controlled pilot study: implications for understanding the placebo effect

Author:

Zafonte Ross D.1234,Fregni Felipe123,Bergin Michael J.G.12,Goldstein Richard1,Boudreau Nancy2,Monge Iris2,Luz Matthew2,Frazier Judith2,Giacino Joseph T.123

Affiliation:

1. Department of Physical Medicine Rehabilitation, Harvard Medical School, Boston, Massachusetts, USA

2. Spaulding Research Institute, Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA

3. Department of Physical Medicine and Rehabilitation, Massachusetts General Hospital, Boston, Massachusetts, USA

4. Brigham & Women’s Hospital, Boston, Massachusetts, USA

Publisher

Informa UK Limited

Subject

Clinical Neurology,Neuroscience (miscellaneous),Developmental and Educational Psychology

Reference39 articles.

1. Centers for Disease Control and Prevention. Report to Congress on Traumatic Brain Injury in the United States: Epidemiology and Rehabilitation. Atlanta (GA): National Center for Injury Prevention and Control; Division of Unintentional Injury Prevention; 2015. [accessed 2019 Apr 2]. https://www.cdc.gov/traumaticbraininjury/pubs/congress_epi_rehab.html.

2. Guidelines for the Pharmacologic Treatment of Neurobehavioral Sequelae of Traumatic Brain Injury

3. Spermidine antagonizes the inhibitory effect of huperzine A on [3H]dizocilpine (MK-801) binding in synaptic membrane of rat cerebral cortex

4. The NMDA receptor ion channel: a site for binding of huperzine A

5. Effects of huperzine A on amyloid precursor protein processing and β-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells

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