In Vitro Reaction Phenotyping and Drug Interaction Data

Author:

Kiang Tony K. L.,Wilby Kyle John,Ensom Mary H. H.

Publisher

Springer Singapore

Reference41 articles.

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2. Voorman RL, Maio SM, Payne NA, Zhao Z, Koeplinger KA, Wang X (1998) Microsomal metabolism of delavirdine: evidence for mechanism-based inactivation of human cytochrome P450 3A. J Pharmacol Exp Ther 287(1):381–388

3. Voorman RL, Payne NA, Wienkers LC, Hauer MJ, Sanders PE (2001) Interaction of delavirdine with human liver microsomal cytochrome P450: inhibition of CYP2C9, CYP2C19, and CYP2D6. Drug Metab Dispos 29(1):41–47

4. Ward BA, Gorski JC, Jones DR, Hall SD, Flockhart DA, Desta Z (2003) The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity. J Pharmacol Exp Ther 306(1):287–300

5. Belanger AS, Caron P, Harvey M, Zimmerman PA, Mehlotra RK, Guillemette C (2009) Glucuronidation of the antiretroviral drug efavirenz by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine. Drug Metab Dispos 37(9):1793–1796

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