Increased DNA-incorporated thiopurine metabolite as a possible mechanism for leukocytopenia through cell apoptosis in inflammatory bowel disease patients with NUDT15 mutation-Reference-Cited by-同舟云学术

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Increased DNA-incorporated thiopurine metabolite as a possible mechanism for leukocytopenia through cell apoptosis in inflammatory bowel disease patients with NUDT15 mutation

Published:2021-09-04 Issue:11 Volume:56 Page:999-1007
ISSN:0944-1174
Container-title:Journal of Gastroenterology
language:en
Short-container-title:J Gastroenterol

Author:

Toyonaga Takahiko,Kobayashi Taku^ORCID,Kuronuma Satoshi,Ueno Aito,Kiyohara Hiroki,Okabayashi Shinji,Takeuchi Osamu,Redfern Christopher P. F.,Terai Hideki,Ozaki Ryo,Sagami Shintaro,Nakano Masaru,Coulthard Sally A.,Tanaka Yoichi,Hibi Toshifumi

Funder

Japan Society for the Promotion of Science

JGW Patterson Foundation

Medical Research Council

Japan Foundation for Applied Enzymology

Ministry of Health, Labour and Welfare

Newcastle Healthcare Charity

Publisher

Springer Science and Business Media LLC

Subject

Gastroenterology

Link

https://link.springer.com/content/pdf/10.1007/s00535-021-01820-0.pdf

Reference30 articles.

1. Kobayashi T, Siegmund B, Le Berre C, et al. Ulcerative colitis. Nat Rev Dis Primers. 2020;6:74.

2. Torres J, Mehandru S, Colombel JF, et al. Crohn’s disease. Lancet. 2017;389:1741–55.

3. Timmer A, Patton PH, Chande N, et al. Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev 2016:CD000478.

4. Chande N, Patton PH, Tsoulis DJ, et al. Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev 2015:CD000067.

5. Derijks LJ, Gilissen LP, Hooymans PM, et al. Review article: thiopurines in inflammatory bowel disease. Aliment Pharmacol Ther. 2006;24:715–29.

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Innovating Thiopurine Therapeutic Drug Monitoring: A Systematic Review and Meta-Analysis on DNA-Thioguanine Nucleotides (DNA-TG) as an Inclusive Biomarker in Thiopurine Therapy;Clinical Pharmacokinetics;2024-07-20

2. Efficacy of Dose Escalation of Oral 5-Aminosalicylic Acid for Ulcerative Colitis With a Mayo Endoscopic Subscore of 1: An Open Label Randomized Controlled Trial;Inflammatory Bowel Diseases;2024-04-24

3. Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers;World Journal of Gastroenterology;2024-03-28

4. Measurement of the intracellular active metabolites of thiopurine drugs to evaluate the enzymatic activity of nudix hydrolase 15 in human blood samples;Journal of Chromatography B;2024-02

5. DNA ‐Thioguanine Nucleotides as a Marker for Thiopurine Induced Late Leukopenia after Dose Optimizing by NUDT15 C415T in Chinese Patients with IBD;Clinical Pharmacology & Therapeutics;2022-09-11

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