Abstract
Abstract
Objectives
Research studies suggest that polycystic ovary syndrome (PCOS) may influence the composition of the oral microflora in women. This study aimed to investigate factors affecting the number of selected periopathogens in a young cohort of females with PCOS and to assess the association between oral hygiene, subgingival microbiome, gingival health, and metabolic and hormonal parameters.
Materials and methods
Thirty-two subjects with PCOS and twenty-three healthy controls aged 15–19 years were examined periodontally by a calibrated dentist. A real-time PCR method was used for the identification of 9 subgingival microorganisms. Subjects with PCOS underwent blood tests for determination of FSH, LH, total testosterone, DHEA-S, estradiol, SHBG, fasting glucose, fasting insulin, and lipid profile.
Results
Gingival index (GI), the proportion of bleeding sites (BOP%), probing depth (PD), and plaque index (PLI) did not differ significantly between cases and healthy age-mates. The control group had significantly higher levels of Peptostreptococcus micros and substantially greater percentage of subjects infected by Treponema denticola. Capnocytophaga gingivalis count was positively correlated with the level of estradiol, while the concentration of HDL-C was negatively correlated with the number of Aggregatibacter actinomycetemcomitans and orange complex bacteria.
Conclusions
PCOS in young patients was not associated with higher pathogenicity of subgingival biofilms.
Clinical relevance
Further studies are needed to explain the relationship between hormonal and metabolic abnormalities, subgingival microflora, and periodontal health in patients with PCOS.
Funder
Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu
Publisher
Springer Science and Business Media LLC
Reference52 articles.
1. Mascarenhas P, Gapski R, Al-Shammari K, Wang HL (2003) Influence of sex hormones on the periodontium. J Clin Periodontol 30:671–681
2. Caton JG, Armitage G, Berglundh T, Chapple ILC, Jepsen S, Kornman KS, Mealey BL, Papapanou PN, Sanz M, Tonetti MS (2018) A new classification scheme for periodontal and peri-implant diseases and conditions - introduction and key changes from the 1999 classification. J Periodontol 89(Suppl 1):S1–S8
3. Kellesarian SV, Malignaggi VR, Kellesarian TV, Al-Kheraif AA, Alwageet MM, Malmstrom H, Romanos GE, Javed F (2017) Association between periodontal disease and polycystic ovary syndrome: a systematic review. Int J Impot Res 29:89–95
4. Özçaka Ö, Ceyhan BO, Akcali A, Bicakci N, Lappin DF, Buduneli N (2012) Is there an interaction between policystic ovary syndrome and gingival inflammation? J Periodontol 83:1529–1537
5. Akcali A, Bostanci N, Özçaka Ö, Öztürk-Ceyhan B, Gümüş P, Buduneli N, Belibasakis GN (2014) Association between polycystic ovary syndrome, oral microbiota and systemic antibody responses. PLoS One 9:e108074
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