Anticoagulant Modulation of Blood Cells and Platelet Reactivity by Garlic Oil in Experimental Diabetes Mellitus-Reference-Cited by-同舟云学术

Anticoagulant Modulation of Blood Cells and Platelet Reactivity by Garlic Oil in Experimental Diabetes Mellitus

Published:2006-06-15 Issue:1 Volume:26 Page:1-6
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Ohaeri O.C.¹²,Adoga G. I.¹²

Affiliation:

1. Department of Biochemistry, Faculty of Medical Sciences, University of JOS, JOS, Nigeria

2. Department of Chemical Sciences, Michael Okpara University of Agriculture, Umudike, PMB 7267, Umuahia, Abia state, Nigeria

Abstract

Multiple blood cell types and metabolic pathways involved in the modulation of platelet reactivity were investigated in streptozotocin-induced diabetic rats treated with garlic oil. Platelet counts of diabetic rats treated with garlic oil were significantly (P<0.01) reduced as compared to diabetic control rats. Garlic oil also increased the leucocyte counts of diabetic rats as compared to diabetic control rats. The significant (P<0.001) decreases by garlic oil of plasma concentration factors, V, VII, VIII: C, IX and X in diabetic rats may be interpreted to mean that there was a modulation of factor VII similar to that brought about by thrombin on factors V and VIII: C. This reversal of hypercoagulation through integrated biochemical reaction is suggestive of multicellular modulation of platelet reactivity, erythrocytes and neutrophils and the functional interactions between plasma coagulation factors and platelet cofactors.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/26/1/1/472525/bsr0260001.pdf

Reference21 articles.

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