Models of hepatic elimination: Comparison of stochastic models to describe residence time distributions and to predict the influence of drug distribution, enzyme heterogeneity, and systemic recycling on hepatic elimination-Reference-Cited by-同舟云学术

Models of hepatic elimination: Comparison of stochastic models to describe residence time distributions and to predict the influence of drug distribution, enzyme heterogeneity, and systemic recycling on hepatic elimination

Published:1988-02 Issue:1 Volume:16 Page:41-83
ISSN:0090-466X
Container-title:Journal of Pharmacokinetics and Biopharmaceutics
language:en
Short-container-title:Journal of Pharmacokinetics and Biopharmaceutics

Author:

Roberts Michael S.,Donaldson John D.,Rowland Malcolm

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics

Link

http://link.springer.com/content/pdf/10.1007/BF01061862.pdf

Reference50 articles.

1. J. G. Wagner.Fundamentals of Clinical Pharmacokinetics, Drug Intelligence Publications, Hamilton, IL, 1975, pp. 57–128.

2. M. Rowland and T. N. Tozer.Clinical Pharmacokinetics: Concepts and Applications, Lea & Febiger, Philadelphia, 1980, pp. 48–76.

3. M. S. Roberts and M. Rowland. Hepatic elimination-dispersion model.J. Pharm. Sci. 74:585–587 (1985).

4. K. S. Pang and M. Rowland. Hepatic clearance of drugs. 1. Theoretical considerations of a “well stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and hepatocellular enzymatic activity on hepatic drug clearance.J. Pharmacokin. Biopharm. 5:625–653 (1977).

5. O. Levenspiel.Chemical Reaction Engineering, Wiley, New York, 1972, pp. 253–315.

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