A Complete Extension of Classical Hepatic Clearance Models Using Fractional Distribution Parameter fd in Physiologically Based Pharmacokinetics
Author:
Funder
National Institute of General Medical Sciences
National Institutes of Health
Publisher
Elsevier BV
Subject
Pharmaceutical Science
Reference113 articles.
1. Generalized solution to linear, two-compartment, open model for drug distribution;Bischoff;J Theor Biol,1970
2. A physiological approach to hepatic drug clearance;Wilkinson;Clin Pharmacol Ther,1975
3. Clearance concepts in pharmacokinetics;Rowland;J Pharmacokinet Biopharm,1973
4. Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance;Pang;J Pharmacokinet Biopharm,1977
5. Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation;Pang;J Pharmacokinet Biopharm,1977
Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. First-in-Human Predictions of Hepatic Clearance for Drugs With the Well-Stirred Model: Comparative Assessment Between Models of Fraction Unbound Based Either on the Free Drug Hypothesis, Albumin-Facilitated Hepatic Uptake or Dynamic Binding Kinetics;Journal of Pharmaceutical Sciences;2024-08
2. A commentary on “Are all measures of liver Kpuu a function of F, as determined following oral dosing, or have we made a critical error in defining hepatic drug clearance?”;European Journal of Pharmaceutical Sciences;2024-07
3. Hepatic OATP1B zonal distribution: Implications for rifampicin‐mediated drug–drug interactions explored within a PBPK framework;CPT: Pharmacometrics & Systems Pharmacology;2024-06-19
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