Baseline T1 hyperintense and diffusion-restricted lesions are not linked to prolonged survival in bevacizumab-treated glioblastoma patients of the GLARIUS trial

Author:

Kebir SiedORCID,Schaub Christina,Junold Nina,Hattingen Elke,Schäfer Niklas,Steinbach Joachim P.,Weyerbrock Astrid,Hau Peter,Goldbrunner Roland,Galldiks Norbert,Weller Johannes,Mack Frederic,Tzaridis Theophilos,Bähr Oliver,Seidel Clemens,Schlegel Uwe,Schmidt-Graf Friederike,Rohde Veit,Borchers Christian,Tabatabai Ghazaleh,Hänel Mathias,Sabel Michael,Gerlach Rüdiger,Krex Dietmar,Belka Claus,Vatter Hartmut,Proescholdt Martin,Glas Martin,Herrlinger Ulrich

Funder

Roche

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Clinical Neurology,Neurology,Oncology

Reference22 articles.

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2. Chinot OL, de La Motte Rouge T, Moore N, Zeaiter A, Das A, Phillips H, Modrusan Z, Cloughesy T (2011) AVAglio: phase 3 trial of bevacizumab plus temozolomide and radiotherapy in newly diagnosed glioblastoma multiforme. Adv Ther 28:334–340. https://doi.org/10.1007/s12325-011-0007-3

3. Herrlinger U, Schafer N, Steinbach JP, Weyerbrock A, Hau P, Goldbrunner R, Friedrich F, Rohde V, Ringel F, Schlegel U, Sabel M, Ronellenfitsch MW, Uhl M, Maciaczyk J, Grau S, Schnell O, Hanel M, Krex D, Vajkoczy P, Gerlach R, Kortmann RD, Mehdorn M, Tuttenberg J, Mayer-Steinacker R, Fietkau R, Brehmer S, Mack F, Stuplich M, Kebir S, Kohnen R, Dunkl E, Leutgeb B, Proescholdt M, Pietsch T, Urbach H, Belka C, Stummer W, Glas M (2016) Bevacizumab plus irinotecan versus temozolomide in newly diagnosed O6-methylguanine-DNA methyltransferase nonmethylated glioblastoma: the randomized GLARIUS trial. J Clin Oncol 34:1611–1619. https://doi.org/10.1200/JCO.2015.63.4691

4. Friedman HS, Prados MD, Wen PY, Mikkelsen T, Schiff D, Abrey LE, Yung WK, Paleologos N, Nicholas MK, Jensen R, Vredenburgh J, Huang J, Zheng M, Cloughesy T (2009) Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol 27:4733–4740. https://doi.org/10.1200/JCO.2008.19.8721

5. Kreisl TN, Kim L, Moore K, Duic P, Royce C, Stroud I, Garren N, Mackey M, Butman JA, Camphausen K, Park J, Albert PS, Fine HA (2009) Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol 27:740–745. https://doi.org/10.1200/JCO.2008.16.3055

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