The in vitro addition of methotrexate and/or methylprednisolone determines peripheral reduction in Th17 and expansion of conventional Treg and of IL-10 producing Th17 lymphocytes in patients with early rheumatoid arthritis-Reference-Cited by-同舟云学术

The in vitro addition of methotrexate and/or methylprednisolone determines peripheral reduction in Th17 and expansion of conventional Treg and of IL-10 producing Th17 lymphocytes in patients with early rheumatoid arthritis

Published:2014-05-03 Issue:1 Volume:35 Page:171-175
ISSN:0172-8172
Container-title:Rheumatology International
language:en
Short-container-title:Rheumatol Int

Author:

Guggino G.,Giardina A.,Ferrante A.,Giardina G.,Schinocca C.,Sireci G.,Dieli F.,Ciccia F.,Triolo G.

Publisher

Springer Science and Business Media LLC

Subject

Immunology,Immunology and Allergy,Rheumatology

Link

http://link.springer.com/content/pdf/10.1007/s00296-014-3030-2.pdf

Reference13 articles.

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2. Wang W, Shao S, Jiao Z, Guo M, Xu H, Wang S (2012) The Th17/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis. Rheumatol Int 32(4):887–893. doi: 10.1007/s00296-010-1710-0

3. Ehrenstein MR, Evans JG, Singh A, Moore S, Warnes G, Isenberg DA et al (2004) Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med 200(3):277–285. doi: 10.1084/jem.20040165

4. Sakaguchi S, Sakaguchi N, Shimizu J, Yamazaki S, Sakihama T, Itoh M et al (2001) Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev 182:18–32

5. Afzali B, Mitchell PJ, Edozie FC, Povoleri GA, Dowson SE, Demandt L et al (2013) CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner. Eur J Immunol 43(8):2043–2054. doi: 10.1002/eji.201243296

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