Short term, low dose alpha-ketoglutarate based polymeric nanoparticles with methotrexate reverse rheumatoid arthritis symptoms in mice and modulate T helper cell responses-Reference-Cited by-同舟云学术

Short term, low dose alpha-ketoglutarate based polymeric nanoparticles with methotrexate reverse rheumatoid arthritis symptoms in mice and modulate T helper cell responses

Published:2022 Issue:23 Volume:10 Page:6688-6697
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Mangal Joslyn L.¹^ORCID,Inamdar Sahil²,Suresh Abhirami P.¹,Jaggarapu Madhan Mohan Chandra Sekhar²^ORCID,Esrafili Arezoo²,Ng Nathan D.³,Acharya Abhinav P.¹²⁴⁵⁶^ORCID

Affiliation:

1. Department of Biological Design, Arizona State University, Tempe, AZ, 85281, USA

2. Department of Chemical Engineering, School for the Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, AZ, 85281, USA

3. Molecular Biosciences and Biotechnology, The College of Liberal Arts and Sciences, Arizona State University, Tempe, AZ, 85281, USA

4. Department of Biomedical Engineering, School of Biological and Health System Engineering, Arizona State University, Tempe, AZ, 85281, USA

5. Department of Materials Science and Engineering, School for the Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, AZ, 85281, USA

6. Center for Immunotherapy, Vaccines and Virotherapy, Arizona State University, Tempe, AZ, 85281, USA

Abstract

Suppressive T cells induce anti-inflammatory responses in rheumatoid arthritis (RA) which then reverse inflammation of the joints.

Funder

Foundation for the National Institutes of Health

National Institute of Allergy and Infectious Diseases

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D2BM00415A