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Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer

  • Published:2009-01-06 Issue:8 Volume:135 Page:1005-1013
  • ISSN:0171-5216
  • Container-title:Journal of Cancer Research and Clinical Oncology
  • language:en
  • Short-container-title:J Cancer Res Clin Oncol

Author:

Ruckhäberle Eugen,Karn Thomas,Rody Achim,Hanker Lars,Gätje Regine,Metzler Dirk,Holtrich Uwe,Kaufmann Manfred

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,General Medicine

Reference56 articles.

1. Ahr A, Karn T, Solbach C, Seiter T, Strebhardt K, Holtrich U, Kaufmann M (2002) Identification of high risk breast-cancer patients by gene expression profiling. Lancet 359:131–132. doi: 10.1016/S0140-6736(02)07337-3

2. Alexe G, Dalgin GS, Scanfeld D, Tamayo P, Mesirov JP, DeLisi C, Harris L, Barnard N, Martel M, Levine AJ, Ganesan S, Bhanot G (2007) High expression of lymphocyte-associated genes in node-negative HER2 + breast cancers correlates with lower recurrence rates. Cancer Res 67:10669–10676. doi: 10.1158/0008-5472.CAN-07-0539

3. Bonnefoi H, Potti A, Delorenzi M, Mauriac L, Campone M, Tubiana-Hulin M, Petit T, Rouanet P, Jassem J, Blot E, Becette V, Farmer P, André S, Acharya CR, Mukherjee S, Cameron D, Bergh J, Nevins JR, Iggo RD (2007) Validation of gene signatures that predict the response of breast cancer to neoadjuvant chemotherapy: a substudy of the EORTC 10994/BIG 00–01 clinical trial. Lancet Oncol 8:1071–1078. doi: 10.1016/S1470-2045(07)70345-5

4. Dahm F, Bielawska A, Nocito A, Georgiev P, Szulc ZM, Bielawski J, Jochum W, Dindo D, Hannun YA, Clavien PA (2008) Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice. Br J Cancer 98(1):98–105

5. Desmedt C, Piette F, Loi S, Wang Y, Lallemand F, Haibe-Kains B, Viale G, Delorenzi M, Zhang Y, d’Assignies MS, Bergh J, Lidereau R, Ellis P, Harris AL, Klijn JG, Foekens JA, Cardoso F, Piccart MJ, Buyse M, Sotiriou C (2007) TRANSBIG Consortium. (2007) Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series. Clin Cancer Res 13:3207–3214

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