Modulation of Oral Bioavailability and Metabolism for Closely Related Cyclic Hexapeptides
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Molecular Medicine,Biochemistry,Bioengineering,Analytical Chemistry
Link
http://link.springer.com/article/10.1007/s10989-017-9590-8/fulltext.html
Reference40 articles.
1. Alex A, Millan DS, Perez M, Wakenhut F, Whitlock GA (2011) Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space. Med Chem Commun 2:669–674
2. Beck JG, Chatterjee J, Laufer B, Kiran MU, Frank AO, Neubauer S, Ovadia O, Greenberg S, Gilon C, Hoffman A, Kessler H (2012) Intestinal permeability of cyclic peptides: common key backbone motifs identified. J Am Chem Soc 134:12125–12133
3. Biron E, Chatterjee J, Ovadia O, Langenegger D, Brueggen J, Hoyer D, Schmid HA, Jelinek R, Gilon C, Hoffman A, Kessler H (2008) Improving oral bioavailability of peptides by multiple N-Methylation: somatostatin analogues. Angew Chem Int Ed 47(14):2595–2599
4. Bockus AT, Lexa KW, Pye CR, Kalgutkar AS, Gardner JW, Hund KCR, Hewitt WM, Schwochert JA, Glassey E, Price DA, Mathiowetz AM, Liras S, Jacobson MP, Lokey RS (2015) Probing the physicochemical boundaries of cell permeability and oral bioavailability in lipophilic macrocycles inspired by natural products. J Med Chem 58:4581–4589
5. Brooks BR, Bruccoleri RE, Olafson BD, States DJ, Swaminathan S, Karplus M (1983) CHARMM: a program for macromolecular energy, minimization, and dynamics calculations. J Comp Chem 4:87–217
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