Redirection of carotenoid metabolism for the efficient production of taxadiene [taxa-4(5),11(12)-diene] in transgenic tomato fruit

Author:

Kovacs Katalin,Zhang Lina,Linforth Robert S. T.,Whittaker Benjamin,Hayes Christopher J.,Fray Rupert G.

Publisher

Springer Science and Business Media LLC

Subject

Agronomy and Crop Science,Genetics,Animal Science and Zoology,Biotechnology

Reference24 articles.

1. Besumbes Ó, Sauret-Güeto S, Phillips MA, Imperial S, Rodriguez-conception M, Boronat A (2004) Metabolic engineering of isoprenoid biosynthesis in Arabidopsis for the production of taxadiene, the first commited precursor of taxol. Biotechnol Bioeng 88:168–175

2. Bevan M (1984) Binary Agrobacterium vectors for plant transformation. Nucleic Acids Res 12:8711–8721

3. Bird CR, Smith CJS, Ray JA, Moureau P, Bevan MW, Bird AS, Hughes S, Morris PC, Grierson D, Schuch W (1988) The tomato polygalacturonase gene and ripening-specific expression in transgenic plants. Plant Mol Biol 13:303–311

4. Brooks T, Mindermann H, O’Loughlin KL, Pera P, Ojima I, Baer MR, Bernacky RJ (2003) Taxane-based reversal agents modulate drug resistance mediated by P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein. Mol Cancer Therap 2:1195–1205

5. Brooks TA, Kennedy DR, Groul DJ, Ojima I, Baer MR, Bernacky RJ (2004) Structure-activity analysis of taxane-based broad-spectrum multidug resistance modulators. Anticancer Res 24:409–415

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