CASC9 potentiates gemcitabine resistance in pancreatic cancer by reciprocally activating NRF2 and the NF-κB signaling pathway-Reference-Cited by-同舟云学术

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CASC9 potentiates gemcitabine resistance in pancreatic cancer by reciprocally activating NRF2 and the NF-κB signaling pathway

Published:2022-08-01 Issue: Volume: Page:
ISSN:0742-2091
Container-title:Cell Biology and Toxicology
language:en
Short-container-title:Cell Biol Toxicol

Author:

Zhang Zhengle,Chen Longjiang,Zhao Chuanbing,Gong Qiong,Tang Zhigang,Li Hanjun,Tao Jing

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Cell Biology,Toxicology

Link

https://link.springer.com/content/pdf/10.1007/s10565-022-09746-w.pdf

Reference39 articles.

1. Abdel Hadi N, Reyes-Castellanos G, Carrier A. Targeting redox metabolism in pancreatic cancer. Int J Mol Sci. 2021;22(4).

2. Arlt A, Gehrz A, Muerkoster S, Vorndamm J, Kruse ML, Folsch UR, et al. Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene. 2003;22(21):3243–51.

3. Arlt A, Schafer H, Kalthoff H. The “N-factors” in pancreatic cancer: functional relevance of NF-kappaB, NFAT and Nrf2 in pancreatic cancer. Oncogenesis. 2012;1:e35.

4. Arora S, Bhardwaj A, Singh S, Srivastava SK, McClellan S, Nirodi CS, et al. An undesired effect of chemotherapy: gemcitabine promotes pancreatic cancer cell invasiveness through reactive oxygen species-dependent, nuclear factor kappaB- and hypoxia-inducible factor 1alpha-mediated up-regulation of CXCR4. J Biol Chem. 2013;288(29):21197–207.

5. Berlin J, Benson AB 3rd. Chemotherapy: gemcitabine remains the standard of care for pancreatic cancer. Nat Rev Clin Oncol. 2010;7(3):135–7.

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