Affiliation:
1. Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University
2. The First College of Clinical Medical Science, China Three Gorges University
Abstract
Abstract:
Reactive Oxygen Species (ROS) and the redoxin system regulate the redox
environment. Thus, they mediate various physiological and pathological processes involved
in tumor occurrence and development by activating redox-sensitive genes and
regulating redox signaling pathways, including tumor cell proliferation, migration, invasion,
and various cell death types. Therefore, the mechanism underlying redox environment
regulation must be clarified to accurately target this mechanism and improve the effect
of tumor treatment. This review introduces redox-sensitive transcription factors and
their activated downstream signaling pathways, and the application of inhibitors targeting
related transcription factors in tumor therapy.
Publisher
Bentham Science Publishers Ltd.