Highlights from Studies Presented at the American Heart Association Scientific Session 2020: Navigating New Roads in Prevention

Author:

Hussain Aliza,Al Rifai Mahmoud,Mahtta Dhruv,Liu Jing,Jain Vardhmaan,Virani Salim S.ORCID

Funder

U.S. Department of Veterans Affairs

Publisher

Springer Science and Business Media LLC

Subject

Cardiology and Cardiovascular Medicine

Reference31 articles.

1. Teerlink JR, Diaz R, Felker GM, McMurray JJV, Metra M, Solomon SD, et al. Cardiac myosin activation with Omecamtiv Mecarbil in systolic heart failure. N Engl J Med. 2020. https://doi.org/10.1056/NEJMoa2025797Randomized controlled trial showing that the primary outcome of cardiovascular death or heart failure was significantly reduced among patients with heart failure with reduced ejection fraction, New York Heart Association (NYHA) functional class II-IV and LVEF ≤35% receiving omecamtiv mecarbil compared to placebo.

2. Bhatt DL, Szarek M, Steg PG, Cannon CP, Leiter LA, McGuire DK, et al. Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure. N Engl J Med. 2020. https://doi.org/10.1056/NEJMoa2030183In patients with a recent admission with HF and previous diagnosis of T2DM, sotagliflozin, when compared to placebo, significantly reduced rate of primary endpoint (cardiovascular mortality, HF hospitalizations).

3. Nicholls SJ, Lincoff AM, Garcia M, Bash D, Ballantyne CM, Barter PJ, et al. Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk: The STRENGTH Randomized Clinical Trial. JAMA. 2020. https://doi.org/10.1001/jama.2020.22258In a multi-centric, double-blinded, randomized, placebo-controlled trial of 13,078 patients with either established ASCVD, diabetes or or high-risk primary prevention patients on maximally tolerated statin therapy, use of of omega-3 CA failed to show significant reduction in cardiovascular events among patients with use compared with corn oil.

4. Kalstad AA, Myhre PL, Laake K, Tveit SH, Schmidt EB, Smith P, et al. Effects of n-3 fatty acid supplements in elderly patients after myocardial infarction. Circulation. 2020. https://doi.org/10.1161/CIRCULATIONAHA.120.052209.

5. Rosenson RS, Burgess LJ, Ebenbichler CF, Baum SJ, Stroes ESG, Ali S, Khilla N, Hamlin R, Pordy R, Dong Y, Son V, Gaudet D. Evinacumab in Patients with Refractory Hypercholesterolemia. N Engl J Med. 2020 Dec 10;383(24):2307–19. https://doi.org/10.1056/NEJMoa2031049.

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