Highlights of Cardiovascular Disease Studies Presented at the 2021 European Society of Cardiology Congress

Author:

Lee Michelle T.,Mahtta Dhruv,Dlouhy Louis,Shahab Hunaina,Al Rifai Mahmoud,Virani Salim S.ORCID

Funder

U.S. Department of Veterans Affairs

American Heart Association

American Diabetes Association

Publisher

Springer Science and Business Media LLC

Subject

Cardiology and Cardiovascular Medicine

Reference31 articles.

1. Anker SD, Butler J, Filippatos G, Ferreira JP, Bocchi E, Böhm M, et al. Empagliflozin in heart failure with a preserved ejection fraction. N Engl J Med. 2021. https://doi.org/10.1056/NEJMoa2107038. In a randomized trial of 5988 heart failure patients with left ventricular ejection fraction >40%, empagliflozin (compared with placebo) was associated with a significant risk reduction in the composite end point of cardiovascular death and first hospitalization for heart failure.

2. Curtain JP, Docherty KF, Jhund PS, Petrie MC, Inzucchi SE, Køber L, et al. Effect of dapagliflozin on ventricular arrhythmias, resuscitated cardiac arrest, or sudden death in DAPA-HF. Eur Heart J. 2021;42(36):3727–38. https://doi.org/10.1093/eurheartj/ehab560. In a randomized trial of 4,744 heart failure patients with reduced left ventricular ejection fraction, dapagliflozin (compared with placebo) was associated with a significant risk reduction in the composite end point of ventricular arrhythmias and sudden death.

3. Joseph P, Roshandel G, Gao P, et al. Fixed-dose combination therapies with and without aspirin for primary prevention of cardiovascular disease: An individual participant data meta-analysis. Lancet. 2021;398(10306):1133–46. https://doi.org/10.1016/S0140-6736(21)01827-4.

4. Doi T, Langsted A, Nordestgaard BG. A possible explanation for the contrasting results of reduce-it vs. Strength: Cohort study mimicking trial designs. Eur Heart J. 2021. https://doi.org/10.1093/eurheartj/ehab555.

5. Nicholls SJ, Nissen SE, Prati F, et al. Assessing the impact of pcsk9 inhibition on coronary plaque phenotype with optical coherence tomography: Rationale and design of the randomized, placebo-controlled huygens study. Cardiovasc Diagn Ther. 2021;11(1):120–9 This international double-blind, placebo-controlled randomized controlled trial of 161 patients demonstrated that adding evolucomab to statin therapy among patients after an acute coronary syndrome resulted in a greater increase in minimum fibrous cap thickness and decrease in maximum lipid arc.

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