Aryl-n-hexanamide linked enaminones of usnic acid as promising antimicrobial agents

Author:

Bangalore Pavan KumarORCID,Pedapati Ravi Kumar,Pranathi Abburi Naga,Batchu Uma Rajeswari,Misra Sunil,Estharala Madhurekha,Sriram Dharmarajan,Kantevari Srinivas

Funder

Science and Engineering Research Board

Publisher

Springer Science and Business Media LLC

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Drug Discovery,Molecular Biology,General Medicine,Information Systems,Catalysis

Reference54 articles.

1. Dyrkheeva N, Luzina O, Filimonov A, Zakharova O, Ilina E, Zakharenko A, Kuprushkin M, Nilov D, Gushchina I, Svedas V, Salakhutdinov N, Lavrik O (2019) Inhibitory effect of new semisynthetic usnic acid derivatives on human tyrosyl-DNA phosphodiesterase 1. Planta Med 85:103–111. https://doi.org/10.1055/a-0681-7069

2. Dyrkheeva NS, Filimonov AS, Luzina OA, Zakharenko AL, Ilina ES, Malakhova AA, Medvedev SP, Reynisson J, Volcho KP, Zakian SM, Salakhutdinov NF, Lavrik OI (2021) New hybrid compounds combining fragments of usnic acid and monoterpenoids for effective tyrosyl-DNA phosphodiesterase 1 inhibition. Biomolecules 11:973–975. https://doi.org/10.3390/biom11070973

3. Zakharenko AL, Luzina OA, Sokolov DN, Kaledin VI, Nikolin VP, Popova NA, Patel J, Zakharova OD, Chepanova AA, Zafar A, Reynisson J, Leung E, Leung IKH, Volcho KP, Salakhutdinov NF, Lavrik OI (2019) Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topotecan on in vivo tumor models. Eur J Med Chem 161:581–593. https://doi.org/10.1016/j.ejmech.2018.10.055

4. Filimonov AS, Chepanova AA, Luzina OA, Zakharenko AL, Zakharova OD, Ilina ES, Dyrkheeva NS, Kuprushkin MS, Kolotaev AV, Khachatryan DS, Patel J, Leung IKH, Chand R, Ayine-Tora DM, Reynisson J, Volcho KP, Salakhutdinov NF, Lavrik OI (2019) New hydrazinothiazole derivatives of usnic acid as potent Tdp1 inhibitor. Molecules 24:3711–3745. https://doi.org/10.3390/molecules24203711

5. Luzina O, Filimonov A, Zakharenko A, Chepanova A, Zakharova O, Ilina E, Dyrkheeva N, Likhatskaya G, Salakhutdinov N, Lavrik O (2020) Usnic acid conjugates with monoterpenoids as potent tyrosyl-DNA phosphodiesterase 1 inhibitors. J Nat Prod 83:2320–2329. https://doi.org/10.1021/acs.jnatprod.9b01089

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